So there is no sufficient resolution in current methods to distinguish compounds with subtle structural changes except for animal or cell assays (Schlessinger et al. Besides, among the anti-cancer drugs, sorafenib and regorafenib show significant differences in activity, but only one difference in structure for the non-hydrogen atom ( i. The reduced false discovery rate was carried out by energizing mitochondria with D-lactate in a mannitol/sucrose-based medium, which indicates the significance of bionic and in vivo environment (Arduino et al. In Arduino’s study, cryopreserved mitochondria isolated from yeast strain were engineered with functional protein and then were employed as a ready-to-use screening reagent. Actually, a more important reason is the lack of biological context during the screening process.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |